Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000427 | uM | 12333.17 | 0.9752 | 0.9263 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00213 | uM | 12333.17 | 1.0085 | 1.0255 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0107 | uM | 12333.17 | 0.9490 | 0.8494 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0533 | uM | 12333.17 | 0.9813 | 0.9443 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.267 | uM | 12333.17 | 0.9797 | 0.9395 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 1.33 | uM | 12333.17 | 0.9458 | 0.8400 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 6.67 | uM | 12333.17 | 0.6488 | 0.0467 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | Bosutinib | Src | nRTK | 33.3 | uM | 12333.17 | 0.6645 | 0.0850 | 0.6683 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.0000853 | uM | 12414.17 | 0.9397 | 0.8994 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.000427 | uM | 12414.17 | 0.9986 | 0.9977 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.00213 | uM | 12414.17 | 0.9920 | 0.9867 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.0107 | uM | 12414.17 | 0.9694 | 0.9492 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.0533 | uM | 12414.17 | 0.9794 | 0.9658 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.267 | uM | 12414.17 | 0.9647 | 0.9412 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 1.33 | uM | 12414.17 | 0.9769 | 0.9616 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 6.67 | uM | 12414.17 | 0.2875 | -0.2891 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 33.3 | uM | 12414.17 | 0.3359 | -0.1912 | 1.2052 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.000256 | uM | 10644.145 | 0.9998 | 0.9992 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.00128 | uM | 10644.145 | 1.0038 | 1.0179 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0064 | uM | 10644.145 | 0.9553 | 0.7982 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.032 | uM | 10644.145 | 1.0528 | 1.2542 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.16 | uM | 10644.145 | 1.0342 | 1.1627 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 0.8 | uM | 10644.145 | 0.6949 | -0.1421 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 4 | uM | 10644.145 | 0.4611 | -0.6694 | 0.4300 | |
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 20 | uM | 10644.145 | 0.0193 | -0.9998 | 0.4300 |