Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.032 | uM | 11055.145 | 1.0121 | 1.0137 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.16 | uM | 11055.145 | 0.9485 | 0.9408 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 0.8 | uM | 11055.145 | 0.6277 | 0.5354 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 4 | uM | 11055.145 | 0.4342 | 0.2455 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 20 | uM | 11055.145 | 0.0643 | -0.5788 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 100 | uM | 11055.145 | 0.0441 | -0.6601 | 1.7616 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10996.145 | 0.9290 | 0.7603 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10996.145 | 1.0450 | 1.1586 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10996.145 | 0.9466 | 0.8184 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10996.145 | 0.9427 | 0.8054 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10996.145 | 1.0453 | 1.1597 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10996.145 | 0.9663 | 0.8846 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10996.145 | 0.8577 | 0.5324 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10996.145 | 0.6626 | -0.0206 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10996.145 | 0.4903 | -0.4192 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 12192.145 | 0.9986 | 0.9933 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 12192.145 | 1.0397 | 1.1957 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 12192.145 | 1.0122 | 1.0592 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 12192.145 | 1.0476 | 1.2359 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 12192.145 | 1.0532 | 1.2642 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 12192.145 | 1.0387 | 1.1904 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 4 | uM | 12192.145 | 0.9099 | 0.5951 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 20 | uM | 12192.145 | 0.6917 | -0.1729 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 100 | uM | 12192.145 | 0.6856 | -0.1903 | 0.4175 | |
| HCC3153 | TNBC | Basal A | Bosutinib | Src | nRTK | 0.000256 | uM | 10577.145 | 0.9441 | 0.8846 | 0.9676 |