Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9118.037 | 0.9571 | 0.9199 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9118.037 | 0.8442 | 0.7081 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9118.037 | 0.4526 | -0.0444 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9118.037 | 0.4607 | -0.0286 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9118.037 | 0.4322 | -0.0847 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9118.037 | 0.3970 | -0.1543 | 1.0733 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9118.037 | 0.1497 | -0.6590 | 1.0733 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7793.037 | 1.0101 | 1.0184 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7793.037 | 1.0177 | 1.0322 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7793.037 | 0.9755 | 0.9552 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7793.037 | 0.8435 | 0.7120 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7793.037 | 0.4662 | -0.0039 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7793.037 | 0.3834 | -0.1668 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7793.037 | 0.3921 | -0.1495 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7793.037 | 0.2268 | -0.4842 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7793.037 | 0.1783 | -0.5860 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9146.037 | 1.0190 | 1.0301 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9146.037 | 1.0214 | 1.0339 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9146.037 | 1.0298 | 1.0471 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9146.037 | 0.7482 | 0.5892 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9146.037 | 0.5261 | 0.2022 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9146.037 | 0.4653 | 0.0906 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9146.037 | 0.4877 | 0.1321 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9146.037 | 0.5215 | 0.1938 | 1.2617 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9146.037 | 0.0176 | -0.9186 | 1.2617 |