Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9878.019 | 0.0745 | -0.6546 | 1.4790 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9033.016 | 1.0171 | 1.0248 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9033.016 | 0.9720 | 0.9591 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9033.016 | 0.9193 | 0.8813 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9033.016 | 0.9243 | 0.8887 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9033.016 | 0.9535 | 0.9318 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9033.016 | 0.9173 | 0.8782 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9033.016 | 0.8187 | 0.7291 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9033.016 | 0.8669 | 0.8025 | 1.3741 | ||
| T47D | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9033.016 | 0.7194 | 0.5737 | 1.3741 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 9045.016 | 1.0720 | 1.1600 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 9045.016 | 0.9092 | 0.7999 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 9045.016 | 1.1626 | 1.3634 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 9045.016 | 0.9329 | 0.8518 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 9045.016 | 1.0962 | 1.2142 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 9045.016 | 0.9566 | 0.9040 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 6.67 | uM | 9045.016 | 0.9337 | 0.8537 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 33.3 | uM | 9045.016 | 0.9147 | 0.8118 | 0.9026 | ||
| UACC-893 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 167 | uM | 9045.016 | 0.7169 | 0.3832 | 0.9026 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.000427 | uM | 7931.016 | 0.9534 | 0.9287 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.00213 | uM | 7931.016 | 0.9101 | 0.8618 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0107 | uM | 7931.016 | 0.9614 | 0.9410 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.0533 | uM | 7931.016 | 0.8615 | 0.7856 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 0.267 | uM | 7931.016 | 0.8633 | 0.7884 | 1.3152 | ||
| ZR-75-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 1.33 | uM | 7931.016 | 0.8432 | 0.7567 | 1.3152 |