Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10695.15 | 0.0544 | -0.7677 | 1.3520 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11852.16 | 0.9283 | 0.8833 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11852.16 | 0.9801 | 0.9677 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 11852.16 | 0.9152 | 0.8618 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 11852.16 | 0.9586 | 0.9329 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 11852.16 | 1.0157 | 1.0253 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 11852.16 | 0.8051 | 0.6787 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 11852.16 | 0.8232 | 0.7093 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 11852.16 | 0.4993 | 0.1414 | 1.2383 | |
| SUM52PE | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 11852.16 | 0.4770 | 0.1000 | 1.2383 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10939.15 | 0.9240 | 0.9085 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10939.15 | 0.9553 | 0.9465 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10939.15 | 0.9529 | 0.9437 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10939.15 | 0.9450 | 0.9341 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10939.15 | 0.9562 | 0.9477 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10939.15 | 0.9542 | 0.9453 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10939.15 | 0.8525 | 0.8197 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10939.15 | 0.7249 | 0.6529 | 1.6881 | |
| T47D | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10939.15 | 0.5548 | 0.4108 | 1.6881 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.000128 | uM | 12608.169 | 0.9771 | 0.9635 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.00064 | uM | 12608.169 | 0.9542 | 0.9268 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.0032 | uM | 12608.169 | 0.9883 | 0.9813 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.016 | uM | 12608.169 | 0.9607 | 0.9372 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.08 | uM | 12608.169 | 0.9936 | 0.9898 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 0.4 | uM | 12608.169 | 0.9896 | 0.9834 | 1.2559 |