Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 10519.138 | 0.9185 | 0.8457 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 10519.138 | 0.9666 | 0.9368 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 10519.138 | 0.9631 | 0.9303 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 10519.138 | 0.9950 | 0.9906 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 10519.138 | 0.9105 | 0.8305 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 10519.138 | 0.9049 | 0.8199 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 10519.138 | 0.8269 | 0.6714 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 10519.138 | 0.8814 | 0.7753 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10998.15 | 0.9515 | 0.8849 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10998.15 | 0.9868 | 0.9687 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10998.15 | 0.9701 | 0.9290 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10998.15 | 0.9917 | 0.9801 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10998.15 | 0.9861 | 0.9669 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10998.15 | 0.9534 | 0.8894 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10998.15 | 0.8307 | 0.6031 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10998.15 | 0.8440 | 0.6339 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10998.15 | 0.7984 | 0.5290 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 12206.16 | 0.9783 | 0.9560 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 12206.16 | 0.9403 | 0.8792 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 12206.16 | 0.9564 | 0.9117 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 12206.16 | 0.9374 | 0.8732 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 12206.16 | 0.9964 | 0.9926 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 12206.16 | 0.8138 | 0.6233 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 12206.16 | 0.7269 | 0.4478 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 12206.16 | 0.6896 | 0.3727 | 0.9874 |