Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0107 | uM | 10753.15 | 0.9778 | 0.9684 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.0533 | uM | 10753.15 | 0.9631 | 0.9475 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 0.267 | uM | 10753.15 | 0.9251 | 0.8927 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 1.33 | uM | 10753.15 | 0.3324 | -0.0828 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 6.67 | uM | 10753.15 | 0.3273 | -0.0928 | 1.4129 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 33.3 | uM | 10753.15 | 0.2868 | -0.1737 | 1.4129 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000128 | uM | 12000.169 | 0.9988 | 0.9972 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00064 | uM | 12000.169 | 0.9743 | 0.9400 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0032 | uM | 12000.169 | 0.9635 | 0.9151 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.016 | uM | 12000.169 | 0.9723 | 0.9354 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.08 | uM | 12000.169 | 0.9805 | 0.9544 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.4 | uM | 12000.169 | 0.9735 | 0.9382 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 2 | uM | 12000.169 | 0.7797 | 0.4958 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 10 | uM | 12000.169 | 0.3262 | -0.4594 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 50 | uM | 12000.169 | 0.1063 | -0.8539 | 0.8565 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.000256 | uM | 12084.16 | 0.9556 | 0.9203 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.00128 | uM | 12084.16 | 1.0464 | 1.0828 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.0064 | uM | 12084.16 | 1.0144 | 1.0257 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.032 | uM | 12084.16 | 0.9608 | 0.9297 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.16 | uM | 12084.16 | 1.0405 | 1.0723 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 0.8 | uM | 12084.16 | 0.7915 | 0.6225 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 4 | uM | 12084.16 | 0.7811 | 0.6033 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 20 | uM | 12084.16 | 0.7706 | 0.5841 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 100 | uM | 12084.16 | 0.2634 | -0.3937 | 1.1178 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000128 | uM | 12001.169 | 0.9420 | 0.8407 | 0.7194 |