Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 2 | uM | 12608.169 | 1.0806 | 1.1273 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 10 | uM | 12608.169 | 0.9808 | 0.9693 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 50 | uM | 12608.169 | 1.0378 | 1.0600 | 1.2559 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 10580.138 | 0.9009 | 0.7937 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 10580.138 | 0.8713 | 0.7322 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 10580.138 | 0.9097 | 0.8119 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 10580.138 | 0.9221 | 0.8377 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 10580.138 | 0.9439 | 0.8831 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 10580.138 | 0.9120 | 0.8168 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 10580.138 | 0.8152 | 0.6159 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 10580.138 | 0.6119 | 0.1979 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 100 | uM | 10580.138 | 0.7656 | 0.5135 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10754.15 | 0.9685 | 0.9457 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10754.15 | 0.9282 | 0.8759 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10754.15 | 0.9253 | 0.8709 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10754.15 | 0.9976 | 0.9958 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10754.15 | 1.0000 | 1.0000 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10754.15 | 0.9132 | 0.8498 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10754.15 | 0.8012 | 0.6528 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10754.15 | 0.5766 | 0.2457 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10754.15 | 0.4384 | -0.0159 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11938.16 | 0.9382 | 0.8102 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11938.16 | 0.9031 | 0.7057 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 11938.16 | 0.9022 | 0.7030 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 11938.16 | 0.9404 | 0.8170 | 0.6405 |