Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.00064 | uM | 12001.169 | 0.9900 | 0.9724 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.0032 | uM | 12001.169 | 0.9561 | 0.8790 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.016 | uM | 12001.169 | 0.9346 | 0.8205 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.08 | uM | 12001.169 | 0.9581 | 0.8846 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 0.4 | uM | 12001.169 | 0.9470 | 0.8541 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 2 | uM | 12001.169 | 0.8843 | 0.6857 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10 | uM | 12001.169 | 0.7003 | 0.2188 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 50 | uM | 12001.169 | 0.4986 | -0.2400 | 0.7194 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0000853 | uM | 10693.15 | 0.9863 | 0.9649 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10693.15 | 0.9706 | 0.9245 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00213 | uM | 10693.15 | 1.0235 | 1.0608 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0107 | uM | 10693.15 | 1.0273 | 1.0707 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0533 | uM | 10693.15 | 1.0521 | 1.1353 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.267 | uM | 10693.15 | 0.9818 | 0.9531 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10693.15 | 0.9341 | 0.8317 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 6.67 | uM | 10693.15 | 0.8124 | 0.5305 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 33.3 | uM | 10693.15 | 0.4634 | -0.2575 | 0.7763 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000256 | uM | 11936.16 | 0.9195 | 0.8212 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.00128 | uM | 11936.16 | 0.8644 | 0.6999 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.0064 | uM | 11936.16 | 0.9702 | 0.9337 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.032 | uM | 11936.16 | 0.9153 | 0.8120 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.16 | uM | 11936.16 | 0.9312 | 0.8470 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.8 | uM | 11936.16 | 0.8621 | 0.6947 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 4 | uM | 11936.16 | 0.8736 | 0.7201 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 20 | uM | 11936.16 | 0.6914 | 0.3250 | 0.8962 |