Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7499.065 | 1.0098 | 1.0362 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7499.065 | 0.9531 | 0.8303 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7499.065 | 0.9157 | 0.6999 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7499.065 | 0.8939 | 0.6260 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7499.065 | 0.6473 | -0.1037 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7499.065 | 0.3125 | -0.7662 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7499.065 | 0.1492 | -0.9403 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7499.065 | 0.0801 | -0.9811 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.048 | uM | 7500.065 | 0.9137 | 0.7915 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 0.24 | uM | 7500.065 | 0.9626 | 0.9091 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 1.2 | uM | 7500.065 | 0.9275 | 0.8247 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 6 | uM | 7500.065 | 0.9488 | 0.8759 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 30 | uM | 7500.065 | 0.8929 | 0.7420 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 150 | uM | 7500.065 | 0.6848 | 0.2604 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 750 | uM | 7500.065 | 0.3663 | -0.4123 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 3750 | uM | 7500.065 | 0.1552 | -0.7938 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 18700 | uM | 7500.065 | 0.0400 | -0.9605 | 0.8201 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.048 | uM | 7504.065 | 1.1602 | 1.1919 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 0.24 | uM | 7504.065 | 1.2403 | 1.2840 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 1.2 | uM | 7504.065 | 1.2984 | 1.3494 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 6 | uM | 7504.065 | 0.8987 | 0.8725 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 30 | uM | 7504.065 | 1.4103 | 1.4722 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 150 | uM | 7504.065 | 0.6811 | 0.5783 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 750 | uM | 7504.065 | 0.1231 | -0.4502 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 3750 | uM | 7504.065 | 0.3657 | 0.0757 | 1.6220 |