Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 15000 | uM | 11055.143 | 0.1194 | -0.4180 | 1.7215 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10996.143 | 0.9995 | 0.9968 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10996.143 | 0.9585 | 0.7390 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10996.143 | 1.0222 | 1.1501 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10996.143 | 1.0151 | 1.1013 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10996.143 | 0.9336 | 0.5948 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10996.143 | 0.9970 | 0.9803 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10996.143 | 0.8827 | 0.3259 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10996.143 | 0.6087 | -0.6104 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10996.143 | 0.0280 | -1.0000 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.0384 | uM | 12192.143 | 0.9348 | 0.7873 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 12192.143 | 1.1182 | 1.4098 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 12192.143 | 0.9888 | 0.9629 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 12192.143 | 1.1059 | 1.3655 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 12192.143 | 0.9336 | 0.7834 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 12192.143 | 1.0036 | 1.0120 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 12192.143 | 1.0190 | 1.0638 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 12192.143 | 0.6763 | 0.0416 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 12192.143 | 0.0372 | -0.9918 | 0.5995 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.0384 | uM | 10577.143 | 1.0169 | 1.0348 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.192 | uM | 10577.143 | 0.9564 | 0.9106 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 0.96 | uM | 10577.143 | 1.0076 | 1.0155 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 4.8 | uM | 10577.143 | 0.9606 | 0.9192 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 24 | uM | 10577.143 | 0.9859 | 0.9710 | 0.9750 | |
| HCC3153 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 120 | uM | 10577.143 | 1.0211 | 1.0433 | 0.9750 |