Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7921.036 | 0.9989 | 0.9968 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7921.036 | 1.0201 | 1.0579 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7921.036 | 0.9555 | 0.8739 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7921.036 | 0.9056 | 0.7352 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7921.036 | 0.8620 | 0.6171 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7921.036 | 0.9069 | 0.7389 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7921.036 | 0.7818 | 0.4059 | 0.6985 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.0000427 | uM | 7536.05 | 0.9965 | 0.9926 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.000213 | uM | 7536.05 | 0.9207 | 0.8334 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.00107 | uM | 7536.05 | 0.9596 | 0.9151 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.00533 | uM | 7536.05 | 0.7128 | 0.4000 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.0267 | uM | 7536.05 | 0.7274 | 0.4302 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.133 | uM | 7536.05 | 0.4989 | -0.0385 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.667 | uM | 7536.05 | 0.5583 | 0.0824 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 3.33 | uM | 7536.05 | 0.5027 | -0.0309 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 16.7 | uM | 7536.05 | 0.4580 | -0.1214 | 0.9494 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.0000427 | uM | 9860.012 | 0.9853 | 0.9828 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.000213 | uM | 9860.012 | 0.9664 | 0.9605 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.00107 | uM | 9860.012 | 0.8741 | 0.8490 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.00533 | uM | 9860.012 | 0.6004 | 0.4853 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.0267 | uM | 9860.012 | 0.4405 | 0.2398 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.133 | uM | 9860.012 | 0.2491 | -0.1110 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 0.667 | uM | 9860.012 | 0.1942 | -0.2311 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 3.33 | uM | 9860.012 | 0.1679 | -0.2937 | 1.7144 | |
| SUM229PE | TNBC | - | Trametinib | MEK | MAPK | 16.7 | uM | 9860.012 | 0.1768 | -0.2722 | 1.7144 |