Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7920.05 | 0.5179 | 0.7075 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7920.05 | 0.4033 | 0.6080 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7920.05 | 0.4007 | 0.6055 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7920.05 | 0.3324 | 0.5351 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7920.05 | 0.2788 | 0.4715 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 9042.05 | 0.9076 | 0.9387 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 9042.05 | 0.6720 | 0.7605 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 9042.05 | 0.8372 | 0.8891 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 9042.05 | 0.6264 | 0.7212 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9042.05 | 0.5819 | 0.6810 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9042.05 | 0.4960 | 0.5970 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9042.05 | 0.5106 | 0.6119 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9042.05 | 0.4673 | 0.5668 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9042.05 | 0.4229 | 0.5173 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 9844.012 | 1.0488 | 1.0423 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 9844.012 | 0.9598 | 0.9643 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 9844.012 | 0.9148 | 0.9233 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 9844.012 | 0.5941 | 0.5913 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9844.012 | 0.4166 | 0.3617 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9844.012 | 0.3855 | 0.3161 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9844.012 | 0.3925 | 0.3266 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9844.012 | 0.3727 | 0.2967 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9844.012 | 0.3154 | 0.2050 | 2.2776 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7921.036 | 1.0192 | 1.0552 | 0.6985 | |
| SUM185PE | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7921.036 | 0.9895 | 0.9700 | 0.6985 |