Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7918.012 | 0.5572 | 0.6431 | 2.9753 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7918.012 | 0.4615 | 0.5423 | 2.9753 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7918.012 | 0.2385 | 0.2353 | 2.9753 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7918.036 | 1.1529 | 1.1002 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7918.036 | 1.0768 | 1.0515 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7918.036 | 0.8297 | 0.8758 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7918.036 | 0.4899 | 0.5653 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7918.036 | 0.5291 | 0.6072 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7918.036 | 0.3292 | 0.3655 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7918.036 | 0.4135 | 0.4767 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7918.036 | 0.3805 | 0.4351 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7918.036 | 0.3138 | 0.3431 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7919.036 | 0.9610 | 0.9782 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7919.036 | 0.9471 | 0.9702 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7919.036 | 0.8228 | 0.8952 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7919.036 | 0.6218 | 0.7542 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7919.036 | 0.4577 | 0.6120 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7919.036 | 0.3659 | 0.5154 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7919.036 | 0.3280 | 0.4703 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7919.036 | 0.3229 | 0.4640 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7919.036 | 0.3773 | 0.5283 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7920.05 | 0.9747 | 0.9877 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7920.05 | 0.9567 | 0.9788 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7920.05 | 0.9179 | 0.9593 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7920.05 | 0.7427 | 0.8620 | 4.1624 |