Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12269.165 | 0.9611 | 0.8721 | 0.6001 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12269.165 | 1.3457 | 2.2804 | 0.6001 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12269.165 | 1.3661 | 2.3638 | 0.6001 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12269.165 | 1.2744 | 1.9960 | 0.6001 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12269.165 | 0.4073 | -0.5524 | 0.6001 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12269.165 | 0.3158 | -0.7071 | 0.6001 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10579.141 | 0.9937 | 0.9858 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10579.141 | 0.9817 | 0.9589 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10579.141 | 0.8692 | 0.7083 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10579.141 | 0.8856 | 0.7447 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 10579.141 | 0.9747 | 0.9431 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 10579.141 | 0.7189 | 0.3799 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 10579.141 | 0.8267 | 0.6146 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 10579.141 | 0.5080 | -0.0662 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 10579.141 | 0.4988 | -0.0851 | 0.8894 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12098.158 | 1.0021 | 1.0036 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12098.158 | 1.0116 | 1.0203 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12098.158 | 0.9273 | 0.8722 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12098.158 | 1.0314 | 1.0548 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 12098.158 | 0.9598 | 0.9294 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 12098.158 | 0.8267 | 0.6934 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 12098.158 | 0.7893 | 0.6262 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 12098.158 | 0.7592 | 0.5719 | 1.1438 | |
| SUM225CWN | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 12098.158 | 0.5209 | 0.1308 | 1.1438 | |
| SUM229PE | TNBC | - | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11058.158 | 0.9150 | 0.9173 | 2.1018 |