Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 11849.135 | 0.9411 | 0.9171 | 1.4337 | |
| HCC1937 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 11849.135 | 0.7426 | 0.6252 | 1.4337 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.000341 | uM | 11055.135 | 1.0003 | 1.0003 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00171 | uM | 11055.135 | 0.9979 | 0.9976 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00853 | uM | 11055.135 | 1.0469 | 1.0543 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 11055.135 | 1.0058 | 1.0067 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 11055.135 | 0.9689 | 0.9634 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 1.07 | uM | 11055.135 | 0.9863 | 0.9839 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 5.33 | uM | 11055.135 | 1.0056 | 1.0065 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 11055.135 | 0.7541 | 0.6958 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 11055.135 | 0.5950 | 0.4765 | 1.7110 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.000341 | uM | 12192.135 | 0.9898 | 0.9673 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.00171 | uM | 12192.135 | 1.1223 | 1.4082 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.00853 | uM | 12192.135 | 0.9656 | 0.8905 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 12192.135 | 1.0795 | 1.2623 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 12192.135 | 0.9669 | 0.8946 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 1.07 | uM | 12192.135 | 0.9675 | 0.8963 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 5.33 | uM | 12192.135 | 1.0824 | 1.2718 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 26.7 | uM | 12192.135 | 0.9028 | 0.6965 | 0.6212 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 133 | uM | 12192.135 | 0.9121 | 0.7247 | 0.6212 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.000341 | uM | 10577.135 | 0.9747 | 0.9530 | 1.0749 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00171 | uM | 10577.135 | 0.9469 | 0.9009 | 1.0749 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.00853 | uM | 10577.135 | 0.9731 | 0.9499 | 1.0749 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 10577.135 | 0.8674 | 0.7521 | 1.0749 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 10577.135 | 0.9680 | 0.9404 | 1.0749 |