Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11938.159 | 1.0314 | 1.1519 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11938.159 | 1.0222 | 1.1069 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11938.159 | 0.9797 | 0.9051 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11938.159 | 1.0430 | 1.2097 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11938.159 | 0.7097 | -0.1127 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11938.159 | 0.0556 | -0.9979 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11938.159 | 0.0223 | -0.9998 | 0.4219 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 11660.152 | 0.9981 | 0.9962 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 11660.152 | 0.9154 | 0.8300 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 11660.152 | 0.9531 | 0.9058 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 11660.152 | 0.9515 | 0.9025 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 11660.152 | 1.0024 | 1.0049 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 11660.152 | 0.9596 | 0.9188 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 11660.152 | 0.7076 | 0.4129 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 11660.152 | 0.3714 | -0.2606 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 11660.152 | 0.3112 | -0.3811 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0000853 | uM | 12003.159 | 0.9714 | 0.9539 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12003.159 | 0.9336 | 0.8927 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12003.159 | 0.9829 | 0.9725 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12003.159 | 0.8626 | 0.7764 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12003.159 | 0.8611 | 0.7739 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12003.159 | 0.8326 | 0.7267 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12003.159 | 0.5010 | 0.1488 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12003.159 | 0.4584 | 0.0697 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12003.159 | 0.2676 | -0.3053 | 1.2466 |