Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Sirolimus | MTOR | MTOR | 33.3 | uM | 7500.069 | 0.7571 | 0.3935 | 0.7701 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.0000853 | uM | 7504.069 | 1.1322 | 1.1399 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.000427 | uM | 7504.069 | 1.2215 | 1.2302 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.00213 | uM | 7504.069 | 1.0381 | 1.0411 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.0107 | uM | 7504.069 | 1.1062 | 1.1130 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.0533 | uM | 7504.069 | 1.1444 | 1.1524 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 0.267 | uM | 7504.069 | 1.1329 | 1.1407 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 1.33 | uM | 7504.069 | 1.2608 | 1.2690 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 6.67 | uM | 7504.069 | 1.3195 | 1.3260 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 33.3 | uM | 7504.069 | 1.0303 | 1.0328 | 1.8361 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.000427 | uM | 7505.068 | 1.0007 | 1.0011 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.00213 | uM | 7505.068 | 0.9231 | 0.8718 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.0107 | uM | 7505.068 | 0.9157 | 0.8594 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.0533 | uM | 7505.068 | 0.7830 | 0.6335 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.267 | uM | 7505.068 | 0.7233 | 0.5297 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 1.33 | uM | 7505.068 | 0.7222 | 0.5278 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 6.67 | uM | 7505.068 | 0.7166 | 0.5180 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 33.3 | uM | 7505.068 | 0.6603 | 0.4186 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 167 | uM | 7505.068 | 0.2767 | -0.3095 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.000427 | uM | 7507.068 | 1.0181 | 1.0333 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.00213 | uM | 7507.068 | 1.0218 | 1.0400 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.0107 | uM | 7507.068 | 0.8710 | 0.7616 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.0533 | uM | 7507.068 | 0.8120 | 0.6516 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 0.267 | uM | 7507.068 | 0.7399 | 0.5161 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 1.33 | uM | 7507.068 | 0.7162 | 0.4715 | 1.0877 |