Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 11938.158 | 0.7818 | 0.3128 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 11938.158 | 0.5228 | -0.3406 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 11938.158 | 0.3513 | -0.6659 | 0.5846 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11660.153 | 0.9146 | 0.7936 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 11660.153 | 0.9027 | 0.7651 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 11660.153 | 0.9645 | 0.9138 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 11660.153 | 0.9475 | 0.8726 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 11660.153 | 0.9580 | 0.8979 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 11660.153 | 0.8509 | 0.6425 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 11660.153 | 0.7602 | 0.4315 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 11660.153 | 0.5749 | 0.0181 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 11660.153 | 0.4354 | -0.2748 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 12003.165 | 0.9728 | 0.9470 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 12003.165 | 0.9562 | 0.9146 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 12003.165 | 0.9292 | 0.8619 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 12003.165 | 0.9160 | 0.8362 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.107 | uM | 12003.165 | 0.9350 | 0.8732 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.533 | uM | 12003.165 | 0.6087 | 0.2333 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 2.67 | uM | 12003.165 | 0.3797 | -0.2212 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 13.3 | uM | 12003.165 | 0.3146 | -0.3517 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 66.7 | uM | 12003.165 | 0.1157 | -0.7554 | 1.0267 | |
| ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000171 | uM | 11939.158 | 0.8978 | 0.8789 | 1.7251 | |
| ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.000853 | uM | 11939.158 | 0.8928 | 0.8728 | 1.7251 | |
| ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.00427 | uM | 11939.158 | 0.9033 | 0.8855 | 1.7251 | |
| ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 0.0213 | uM | 11939.158 | 0.8667 | 0.8408 | 1.7251 |