Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.00213 | uM | 7898.029 | 1.2559 | 1.7531 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.00213 | uM | 7898.029 | 1.2559 | 1.7531 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.0107 | uM | 7898.029 | 0.9061 | 0.7417 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.0107 | uM | 7898.029 | 0.9061 | 0.7417 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.0533 | uM | 7898.029 | 1.2902 | 1.8591 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.0533 | uM | 7898.029 | 1.2902 | 1.8591 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.267 | uM | 7898.029 | 0.7365 | 0.3023 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 0.267 | uM | 7898.029 | 0.7365 | 0.3023 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 1.33 | uM | 7898.029 | 1.3185 | 1.9474 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 1.33 | uM | 7898.029 | 1.3185 | 1.9474 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 6.67 | uM | 7898.029 | 1.1001 | 1.2864 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 6.67 | uM | 7898.029 | 1.1001 | 1.2864 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 33.3 | uM | 7898.029 | 1.1857 | 1.5397 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 33.3 | uM | 7898.029 | 1.1857 | 1.5397 | 0.7130 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12414.155 | 0.9478 | 0.9155 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12414.155 | 0.9478 | 0.9155 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 12414.155 | 0.9101 | 0.8540 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.000427 | uM | 12414.155 | 0.9101 | 0.8540 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 12414.155 | 0.9676 | 0.9476 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.00213 | uM | 12414.155 | 0.9676 | 0.9476 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 12414.155 | 0.9647 | 0.9429 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0107 | uM | 12414.155 | 0.9647 | 0.9429 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 12414.155 | 1.0214 | 1.0345 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.0533 | uM | 12414.155 | 1.0214 | 1.0345 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | PD184352 | MEK | MAPK | 0.267 | uM | 12414.155 | 0.9679 | 0.9481 | 1.2420 |