Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 7553.093 | 0.9707 | 0.9487 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 7553.093 | 0.9686 | 0.9450 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 7553.093 | 0.9721 | 0.9511 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 7553.093 | 0.9445 | 0.9026 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 7553.093 | 0.9372 | 0.8896 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 7553.093 | 0.9028 | 0.8288 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 7553.093 | 0.9172 | 0.8544 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 7553.093 | 0.4719 | 0.0366 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 10444.093 | 0.9809 | 0.9649 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 10444.093 | 0.9518 | 0.9114 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 10444.093 | 0.9214 | 0.8553 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 10444.093 | 0.9021 | 0.8197 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 10444.093 | 0.9293 | 0.8700 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 10444.093 | 0.8776 | 0.7743 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 10444.093 | 0.8981 | 0.8122 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 10444.093 | 0.8636 | 0.7483 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 10444.093 | 0.2459 | -0.4476 | 1.0902 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12509.155 | 1.0051 | 1.0076 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.0000853 | uM | 12509.155 | 1.0051 | 1.0076 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.000427 | uM | 12509.155 | 1.0607 | 1.0896 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.000427 | uM | 12509.155 | 1.0607 | 1.0896 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.00213 | uM | 12509.155 | 1.0272 | 1.0403 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.00213 | uM | 12509.155 | 1.0272 | 1.0403 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.0107 | uM | 12509.155 | 1.0571 | 1.0843 | 1.3444 | |
| 184A1 | NM | Basal | PD184352 | MEK | MAPK | 0.0107 | uM | 12509.155 | 1.0571 | 1.0843 | 1.3444 |