Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0213 | uM | 7472.1 | 1.3041 | 1.5394 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.107 | uM | 7472.1 | 1.4548 | 1.8019 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.533 | uM | 7472.1 | 1.2727 | 1.4844 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 2.67 | uM | 7472.1 | 2.7719 | 4.0030 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 13.3 | uM | 7472.1 | 1.5934 | 2.0409 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 66.7 | uM | 7472.1 | 0.0007 | -0.9972 | 1.1120 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 10379.093 | 1.0382 | 1.0333 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 10379.093 | 0.9789 | 0.9813 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 10379.093 | 1.0803 | 1.0692 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 10379.093 | 1.0462 | 1.0402 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 10379.093 | 1.0413 | 1.0359 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 10379.093 | 1.0163 | 1.0143 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 10379.093 | 0.8957 | 0.9052 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 10379.093 | 0.4948 | 0.4670 | 2.2706 | |
| Hs 578T | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 10379.093 | 0.0816 | -0.3365 | 2.2706 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 10380.093 | 1.0810 | 1.1075 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.000427 | uM | 10380.093 | 1.0482 | 1.0643 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.00213 | uM | 10380.093 | 1.0711 | 1.0945 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0107 | uM | 10380.093 | 0.9641 | 0.9515 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.0533 | uM | 10380.093 | 1.0229 | 1.0306 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 0.267 | uM | 10380.093 | 0.9954 | 0.9939 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 1.33 | uM | 10380.093 | 1.0531 | 1.0707 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 6.67 | uM | 10380.093 | 0.8295 | 0.7638 | 1.4880 | |
| LY2 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 33.3 | uM | 10380.093 | 0.1587 | -0.4195 | 1.4880 | |
| MCF 10A | NM | Basal B | PD173074 | FGFR1/3 | RTK | 0.0000853 | uM | 7485.093 | 0.9919 | 0.9955 | 3.5766 |