Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 12333.152 | 0.8427 | 0.5855 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 12333.152 | 0.5791 | -0.0468 | 0.7371 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.000128 | uM | 12414.152 | 0.8706 | 0.7696 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.00064 | uM | 12414.152 | 0.9148 | 0.8487 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.0032 | uM | 12414.152 | 0.9349 | 0.8847 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.016 | uM | 12414.152 | 0.9780 | 0.9611 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.08 | uM | 12414.152 | 0.9965 | 0.9939 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 0.4 | uM | 12414.152 | 0.9727 | 0.9517 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 2 | uM | 12414.152 | 0.9778 | 0.9607 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 10 | uM | 12414.152 | 0.9354 | 0.8854 | 1.1325 | |
| MDA-MB-453 | TNBC | Luminal | PD 98059 | MEK | MAPK | 50 | uM | 12414.152 | 0.9755 | 0.9567 | 1.1325 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.000256 | uM | 10644.136 | 1.0065 | 1.0234 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.00128 | uM | 10644.136 | 0.9710 | 0.8968 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.0064 | uM | 10644.136 | 1.0083 | 1.0298 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.032 | uM | 10644.136 | 0.9030 | 0.6649 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.16 | uM | 10644.136 | 1.0410 | 1.1497 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.8 | uM | 10644.136 | 1.0206 | 1.0748 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 4 | uM | 10644.136 | 0.9930 | 0.9748 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 20 | uM | 10644.136 | 0.9758 | 0.9137 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 100 | uM | 10644.136 | 0.8129 | 0.3780 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.000128 | uM | 10874.152 | 0.9194 | 0.7934 | 0.7706 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.00064 | uM | 10874.152 | 0.9752 | 0.9360 | 0.7706 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.0032 | uM | 10874.152 | 0.9732 | 0.9307 | 0.7706 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.016 | uM | 10874.152 | 0.9794 | 0.9467 | 0.7706 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 0.08 | uM | 10874.152 | 0.9437 | 0.8550 | 0.7706 |