Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 7531.066 | 1.1049 | 1.0611 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7531.066 | 1.0469 | 1.0279 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7531.066 | 1.1251 | 1.0724 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7531.066 | 0.9754 | 0.9850 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7531.066 | 1.0031 | 1.0019 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7531.066 | 1.1103 | 1.0642 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7531.066 | 1.0332 | 1.0198 | 3.3129 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7531.066 | 1.0326 | 1.0194 | 3.3129 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7532.066 | 0.9792 | 0.9539 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7532.066 | 0.9670 | 0.9268 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7532.066 | 0.9576 | 0.9061 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7532.066 | 0.9529 | 0.8957 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7532.066 | 0.9615 | 0.9147 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7532.066 | 0.8882 | 0.7535 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7532.066 | 0.8857 | 0.7479 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7532.066 | 0.5724 | 0.0768 | 0.9011 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7532.066 | 0.3388 | -0.3983 | 0.9011 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7533.066 | 1.0253 | 1.0584 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.000427 | uM | 7533.066 | 1.0254 | 1.0586 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.00213 | uM | 7533.066 | 0.9584 | 0.9044 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0107 | uM | 7533.066 | 1.0098 | 1.0225 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.0533 | uM | 7533.066 | 1.0163 | 1.0376 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 0.267 | uM | 7533.066 | 0.9517 | 0.8891 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 1.33 | uM | 7533.066 | 1.0168 | 1.0389 | 0.8676 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 6.67 | uM | 7533.066 | 0.8031 | 0.5533 | 0.8676 |