Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 1.33 | uM | 11660.152 | 0.8841 | 0.7671 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 6.67 | uM | 11660.152 | 0.2610 | -0.4813 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 11660.152 | 0.0130 | -0.9745 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 167 | uM | 11660.152 | 0.0104 | -0.9796 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.000427 | uM | 12003.159 | 0.8515 | 0.7579 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.00213 | uM | 12003.159 | 0.8222 | 0.7094 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0107 | uM | 12003.159 | 0.9053 | 0.8466 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0533 | uM | 12003.159 | 0.8429 | 0.7438 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.267 | uM | 12003.159 | 0.7265 | 0.5478 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 1.33 | uM | 12003.159 | 0.7106 | 0.5205 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 6.67 | uM | 12003.159 | 0.0112 | -0.9454 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12003.159 | 0.0106 | -0.9477 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 167 | uM | 12003.159 | 0.0077 | -0.9596 | 1.2466 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.000427 | uM | 11939.159 | 0.9994 | 0.9993 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.00213 | uM | 11939.159 | 0.9915 | 0.9896 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0107 | uM | 11939.159 | 0.9671 | 0.9593 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0533 | uM | 11939.159 | 0.9816 | 0.9773 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.267 | uM | 11939.159 | 0.9740 | 0.9679 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 1.33 | uM | 11939.159 | 1.0354 | 1.0432 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 6.67 | uM | 11939.159 | 0.2813 | -0.0827 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 11939.159 | 0.0127 | -0.8631 | 1.6270 | |
| ZR75B | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 167 | uM | 11939.159 | 0.0124 | -0.8656 | 1.6270 | |
| 184A1 | NM | Basal | NU6102 | CDK1/2 | CDK | 0.000171 | uM | 12509.147 | 1.0354 | 1.0585 | 1.2058 | |
| 184A1 | NM | Basal | NU6102 | CDK1/2 | CDK | 0.000853 | uM | 12509.147 | 1.0796 | 1.1312 | 1.2058 | |
| 184A1 | NM | Basal | NU6102 | CDK1/2 | CDK | 0.00427 | uM | 12509.147 | 1.0530 | 1.0875 | 1.2058 |