Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Nilotinib | ABL | nRTK | 40 | uM | 11939.145 | 0.9917 | 0.9902 | 1.6830 | |
| ZR75B | HR+ | Luminal | Nilotinib | ABL | nRTK | 200 | uM | 11939.145 | 0.9261 | 0.9109 | 1.6830 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.000427 | uM | 12509.152 | 1.0197 | 1.0285 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.00213 | uM | 12509.152 | 0.9543 | 0.9332 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.0107 | uM | 12509.152 | 0.9728 | 0.9603 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.0533 | uM | 12509.152 | 0.9250 | 0.8898 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.267 | uM | 12509.152 | 1.0254 | 1.0369 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 1.33 | uM | 12509.152 | 0.8394 | 0.7610 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 6.67 | uM | 12509.152 | 0.0118 | -0.9206 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12509.152 | 0.0103 | -0.9284 | 1.3755 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 167 | uM | 12509.152 | 0.0099 | -0.9303 | 1.3755 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.000427 | uM | 12566.152 | 1.0496 | 1.0664 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.00213 | uM | 12566.152 | 0.9618 | 0.9482 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.0107 | uM | 12566.152 | 0.9898 | 0.9862 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.0533 | uM | 12566.152 | 1.0059 | 1.0079 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 0.267 | uM | 12566.152 | 1.0898 | 1.1194 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 1.33 | uM | 12566.152 | 0.9324 | 0.9078 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 6.67 | uM | 12566.152 | 0.0504 | -0.7336 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 33.3 | uM | 12566.152 | 0.0169 | -0.8725 | 1.4827 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 167 | uM | 12566.152 | 0.0143 | -0.8860 | 1.4827 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.000427 | uM | 12224.152 | 0.9548 | 0.9158 | 1.0761 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.00213 | uM | 12224.152 | 0.9618 | 0.9289 | 1.0761 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0107 | uM | 12224.152 | 0.9609 | 0.9272 | 1.0761 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.0533 | uM | 12224.152 | 0.9844 | 0.9710 | 1.0761 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 0.267 | uM | 12224.152 | 1.0068 | 1.0127 | 1.0761 |