Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.0000853 | uM | 12677.174 | 1.0249 | 1.0498 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.000427 | uM | 12677.174 | 1.0106 | 1.0212 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.00213 | uM | 12677.174 | 0.9843 | 0.9685 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.0107 | uM | 12677.174 | 1.0292 | 1.0584 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.0533 | uM | 12677.174 | 0.9746 | 0.9491 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 0.267 | uM | 12677.174 | 0.9566 | 0.9130 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 1.33 | uM | 12677.174 | 0.9408 | 0.8816 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 6.67 | uM | 12677.174 | 0.9028 | 0.8055 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 33.3 | uM | 12677.174 | 0.1145 | -0.7713 | 0.9992 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.0000853 | uM | 13595.174 | 0.9739 | 0.9717 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.000427 | uM | 13595.174 | 0.9720 | 0.9697 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.00213 | uM | 13595.174 | 0.9916 | 0.9909 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.0107 | uM | 13595.174 | 0.9982 | 0.9981 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.0533 | uM | 13595.174 | 0.9539 | 0.9498 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 0.267 | uM | 13595.174 | 0.9826 | 0.9812 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 1.33 | uM | 13595.174 | 0.9244 | 0.9173 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 6.67 | uM | 13595.174 | 0.6669 | 0.6085 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Nelfinavir | 33.3 | uM | 13595.174 | 0.0962 | -0.4322 | 1.8596 | |||
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.000512 | uM | 12509.17 | 1.0051 | 1.0074 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.00256 | uM | 12509.17 | 1.0256 | 1.0365 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.0128 | uM | 12509.17 | 0.9642 | 0.9484 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.064 | uM | 12509.17 | 0.9781 | 0.9686 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.32 | uM | 12509.17 | 0.9479 | 0.9248 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 1.6 | uM | 12509.17 | 0.8925 | 0.8434 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 8 | uM | 12509.17 | 0.9098 | 0.8689 | 1.3955 |