Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7506.085 | 0.6651 | 0.3798 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7506.085 | 0.6682 | 0.3857 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7506.085 | 0.6634 | 0.3766 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7506.085 | 0.6492 | 0.3497 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7506.085 | 0.6618 | 0.3735 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7507.084 | 0.9909 | 0.9837 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7507.084 | 0.9584 | 0.9256 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7507.084 | 1.0059 | 1.0105 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7507.084 | 0.8297 | 0.6931 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7507.084 | 0.4853 | 0.0493 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7507.084 | 0.5621 | 0.1962 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7507.084 | 0.5442 | 0.1622 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7507.084 | 0.5197 | 0.1154 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7507.084 | 0.5303 | 0.1357 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7508.084 | 1.0315 | 1.0816 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7508.084 | 0.9737 | 0.9325 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 7508.084 | 0.9649 | 0.9101 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 7508.084 | 0.8860 | 0.7109 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 0.533 | uM | 7508.084 | 0.4434 | -0.2991 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 2.67 | uM | 7508.084 | 0.4331 | -0.3201 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 7508.084 | 0.4147 | -0.3571 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 7508.084 | 0.4382 | -0.3097 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 7508.084 | 0.4259 | -0.3345 | 0.7756 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 7510.084 | 1.0620 | 1.1432 | 0.8702 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 7510.084 | 0.9362 | 0.8541 | 0.8702 |