Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5908.084 | 0.9003 | 0.6124 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5908.084 | 0.8735 | 0.5153 | 0.4873 | |
| BT-483 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 333 | uM | 5908.084 | 0.8493 | 0.4303 | 0.4873 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5909.085 | 1.0943 | 1.0593 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5909.085 | 1.0734 | 1.0465 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5909.085 | 1.0719 | 1.0455 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5909.085 | 1.0497 | 1.0317 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5909.085 | 0.9688 | 0.9795 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5909.085 | 1.0483 | 1.0308 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5909.085 | 0.9806 | 0.9873 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5909.085 | 0.8957 | 0.9298 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 5909.085 | 0.9428 | 0.9622 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5910.084 | 1.0443 | 1.0281 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5910.084 | 1.0093 | 1.0060 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5910.084 | 1.0327 | 1.0208 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5910.084 | 1.0719 | 1.0452 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 0.533 | uM | 5910.084 | 1.0656 | 1.0413 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 2.67 | uM | 5910.084 | 1.0226 | 1.0144 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 13.3 | uM | 5910.084 | 1.0769 | 1.0482 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 66.7 | uM | 5910.084 | 0.9058 | 0.9374 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 333 | uM | 5910.084 | 0.9088 | 0.9394 | 3.1096 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.000853 | uM | 5911.084 | 0.9816 | 0.9642 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.00427 | uM | 5911.084 | 0.9683 | 0.9382 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.0213 | uM | 5911.084 | 0.9290 | 0.8614 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 0.107 | uM | 5911.084 | 0.7438 | 0.4989 | 1.0262 |