Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 12003.165 | 0.8757 | 0.7574 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 12003.165 | 0.8940 | 0.7932 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 12003.165 | 0.8627 | 0.7320 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 12003.165 | 0.7402 | 0.4920 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 12003.165 | 0.2324 | -0.5172 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 12003.165 | 0.0098 | -0.9780 | 1.0267 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 11939.158 | 0.9172 | 0.9022 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11939.158 | 0.8974 | 0.8783 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 11939.158 | 0.8877 | 0.8666 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 11939.158 | 0.8797 | 0.8568 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11939.158 | 0.8158 | 0.7774 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11939.158 | 0.9007 | 0.8824 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11939.158 | 0.6938 | 0.6180 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11939.158 | 0.0171 | -0.8106 | 1.7251 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11939.158 | 0.0066 | -0.8910 | 1.7251 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5894.066 | 1.0769 | 1.1011 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.000427 | uM | 5894.066 | 1.0325 | 1.0430 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.00213 | uM | 5894.066 | 0.9885 | 0.9847 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.0107 | uM | 5894.066 | 1.0745 | 1.0980 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.0533 | uM | 5894.066 | 1.0550 | 1.0725 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.267 | uM | 5894.066 | 0.5092 | 0.2764 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 1.33 | uM | 5894.066 | 0.4506 | 0.1766 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 6.67 | uM | 5894.066 | 0.4167 | 0.1169 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 33.3 | uM | 5894.066 | 0.3766 | 0.0442 | 1.5027 | |
| 184A1 | NM | Basal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 5895.066 | 1.0403 | 1.0693 | 1.1612 |