Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 12239.165 | 0.6970 | 0.6800 | 2.0705 | |
| HCC1806 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 12239.165 | 0.4193 | 0.3143 | 2.0705 | |
| HCC1806 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 12239.165 | 0.0137 | -0.7484 | 2.0705 | |
| HCC1806 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 12239.165 | 0.0073 | -0.8147 | 2.0705 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 11849.158 | 0.9444 | 0.9202 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11849.158 | 1.0167 | 1.0237 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 11849.158 | 0.9171 | 0.8806 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 11849.158 | 0.8090 | 0.7201 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11849.158 | 0.7836 | 0.6814 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11849.158 | 0.8486 | 0.7794 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11849.158 | 0.6644 | 0.4951 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11849.158 | 0.1400 | -0.5062 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11849.158 | 0.0078 | -0.9368 | 1.4054 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 11055.158 | 0.9475 | 0.9373 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 11055.158 | 1.0197 | 1.0232 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 11055.158 | 0.9688 | 0.9629 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.0213 | uM | 11055.158 | 1.0009 | 1.0010 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.107 | uM | 11055.158 | 0.5126 | 0.3483 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 0.533 | uM | 11055.158 | 0.4111 | 0.1837 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 2.67 | uM | 11055.158 | 0.2719 | -0.0726 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 13.3 | uM | 11055.158 | 0.0345 | -0.7256 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 66.7 | uM | 11055.158 | 0.0088 | -0.8774 | 1.6948 | |
| HCC2185 | TNBC | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000171 | uM | 12192.158 | 0.9921 | 0.9765 | 0.6680 | |
| HCC2185 | TNBC | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.000853 | uM | 12192.158 | 1.0296 | 1.0892 | 0.6680 | |
| HCC2185 | TNBC | Luminal | Afatinib | EGFR/HER2 | ErbB | 0.00427 | uM | 12192.158 | 0.9417 | 0.8280 | 0.6680 |