Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | LBH589 | HDAC | HDAC | 1.33 | uM | 11936.154 | 0.0122 | -0.9904 | 0.8259 | |
| HCC1428 | HR+ | Luminal | LBH589 | HDAC | HDAC | 6.67 | uM | 11936.154 | 0.0145 | -0.9882 | 0.8259 | |
| HCC1428 | HR+ | Luminal | LBH589 | HDAC | HDAC | 33.3 | uM | 11936.154 | 0.0146 | -0.9880 | 0.8259 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10872.154 | 1.0275 | 1.0393 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 10872.154 | 1.0850 | 1.1202 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 10872.154 | 1.0605 | 1.0858 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 10872.154 | 1.1623 | 1.2272 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 10872.154 | 0.9155 | 0.8775 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 10872.154 | 0.4187 | 0.0727 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 10872.154 | 0.0787 | -0.6755 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 10872.154 | 0.0563 | -0.7447 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 10872.154 | 0.0430 | -0.7895 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12523.167 | 0.9508 | 0.9053 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 12523.167 | 0.9726 | 0.9472 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 12523.167 | 0.9776 | 0.9570 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 12523.167 | 0.9767 | 0.9552 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 12523.167 | 0.8725 | 0.7541 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 12523.167 | 0.6476 | 0.3169 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 12523.167 | 0.1931 | -0.5887 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 12523.167 | 0.0744 | -0.8357 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 12523.167 | 0.0562 | -0.8745 | 1.0398 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12239.154 | 0.9760 | 0.9781 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 12239.154 | 0.9386 | 0.9433 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 12239.154 | 1.0443 | 1.0398 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 12239.154 | 1.0063 | 1.0057 | 2.2015 |