Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7552.098 | 0.9358 | 0.8913 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7552.098 | 0.8971 | 0.8252 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7552.098 | 0.9318 | 0.8845 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7552.098 | 0.9443 | 0.9058 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7552.098 | 0.8967 | 0.8246 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7553.098 | 0.9652 | 0.9434 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7553.098 | 0.8877 | 0.8158 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7553.098 | 0.9300 | 0.8857 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7553.098 | 0.9421 | 0.9056 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7553.098 | 0.9326 | 0.8899 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7553.098 | 0.9156 | 0.8619 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7553.098 | 0.9122 | 0.8563 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7553.098 | 0.8950 | 0.8279 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7553.098 | 0.9071 | 0.8478 | 1.2325 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7555.098 | 0.9874 | 0.9847 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7555.098 | 0.9365 | 0.9220 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7555.098 | 1.0114 | 1.0137 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7555.098 | 1.0334 | 1.0403 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7555.098 | 1.0218 | 1.0263 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7555.098 | 0.9453 | 0.9329 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7555.098 | 0.9784 | 0.9738 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7555.098 | 1.0049 | 1.0060 | 1.6495 | |
| ZR75B | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7555.098 | 0.9494 | 0.9380 | 1.6495 | |
| 184A1 | NM | Basal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 12509.167 | 1.0480 | 1.0669 | 1.4256 | |
| 184A1 | NM | Basal | LBH589 | HDAC | HDAC | 0.000427 | uM | 12509.167 | 1.0503 | 1.0701 | 1.4256 |