Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7523.098 | 0.9974 | 0.9940 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7523.098 | 0.9657 | 0.9231 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7523.098 | 1.0228 | 1.0513 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7523.098 | 0.9979 | 0.9952 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7523.098 | 0.9873 | 0.9716 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7523.098 | 0.9968 | 0.9928 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7523.098 | 0.9777 | 0.9500 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7523.098 | 0.8358 | 0.6348 | 0.8897 | |
| MX1 | Unknown | Unknown | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7523.098 | 0.7413 | 0.4285 | 0.8897 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7526.098 | 0.9774 | 0.9703 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7526.098 | 0.9581 | 0.9447 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7526.098 | 0.9941 | 0.9923 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7526.098 | 1.0298 | 1.0389 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7526.098 | 0.9620 | 0.9498 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7526.098 | 0.8750 | 0.8324 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7526.098 | 0.7349 | 0.6344 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 7526.098 | 0.3799 | 0.0607 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 7526.098 | 0.3271 | -0.0384 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 7527.098 | 1.0153 | 1.0176 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 7527.098 | 0.9943 | 0.9934 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 7527.098 | 0.9519 | 0.9437 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 7527.098 | 0.9845 | 0.9820 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 7527.098 | 0.9862 | 0.9840 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 7527.098 | 0.7324 | 0.6699 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 7527.098 | 0.3841 | 0.1490 | 1.7263 |