Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11850.157 | 0.5139 | 0.4554 | 2.0943 | |
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 11850.157 | 0.3103 | 0.1438 | 2.0943 | |
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 11850.157 | 0.3604 | 0.2286 | 2.0943 | |
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 11850.157 | 0.2464 | 0.0246 | 2.0943 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10873.151 | 0.9254 | 0.8727 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10873.151 | 1.0286 | 1.0484 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10873.151 | 0.9695 | 0.9481 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10873.151 | 0.9219 | 0.8667 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10873.151 | 0.9264 | 0.8744 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10873.151 | 0.9615 | 0.9344 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10873.151 | 0.8511 | 0.7443 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10873.151 | 0.8153 | 0.6818 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10873.151 | 0.8598 | 0.7595 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12400.157 | 0.9844 | 0.9738 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12400.157 | 0.9142 | 0.8552 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12400.157 | 0.9395 | 0.8981 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12400.157 | 0.9096 | 0.8474 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12400.157 | 0.9739 | 0.9561 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12400.157 | 0.8561 | 0.7559 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 12400.157 | 0.8511 | 0.7472 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 12400.157 | 0.7863 | 0.6350 | 1.1935 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 12400.157 | 0.7748 | 0.6151 | 1.1935 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10694.151 | 0.9206 | 0.9332 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10694.151 | 0.9981 | 0.9984 | 2.4341 | |
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10694.151 | 0.9742 | 0.9787 | 2.4341 |