Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7496.088 | 0.9691 | 0.9390 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7496.088 | 0.9509 | 0.9030 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7496.088 | 0.8736 | 0.7504 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7496.088 | 0.9545 | 0.9101 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7496.088 | 0.9609 | 0.9229 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7496.088 | 0.9319 | 0.8656 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7496.088 | 0.9226 | 0.8472 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7496.088 | 0.9167 | 0.8355 | 1.0135 | |
| MDA-MB-157 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7496.088 | 0.9439 | 0.8892 | 1.0135 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7506.088 | 1.0157 | 1.0300 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7506.088 | 0.9746 | 0.9512 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7506.088 | 1.0011 | 1.0020 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7506.088 | 0.9722 | 0.9466 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7506.088 | 0.9368 | 0.8784 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7506.088 | 0.9367 | 0.8783 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7506.088 | 0.9822 | 0.9659 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7506.088 | 0.9949 | 0.9902 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7506.088 | 0.9752 | 0.9523 | 1.0417 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7517.088 | 1.0193 | 1.0263 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7517.088 | 0.9130 | 0.8798 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7517.088 | 0.9406 | 0.9183 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7517.088 | 0.9925 | 0.9898 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7517.088 | 0.9812 | 0.9744 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7517.088 | 0.9493 | 0.9304 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7517.088 | 0.9401 | 0.9177 | 1.4687 |