Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7485.088 | 0.9328 | 0.9625 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7485.088 | 1.0525 | 1.0280 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7485.088 | 1.0019 | 1.0010 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7485.088 | 0.9778 | 0.9878 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7485.088 | 0.9286 | 0.9601 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7485.088 | 1.0380 | 1.0204 | 3.6725 | |
| MCF 10A | NM | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7485.088 | 0.4907 | 0.6475 | 3.6725 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7490.088 | 1.0348 | 1.0271 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7490.088 | 0.9707 | 0.9767 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7490.088 | 0.9819 | 0.9857 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7490.088 | 0.9943 | 0.9955 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7490.088 | 0.9687 | 0.9751 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7490.088 | 0.9786 | 0.9830 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7490.088 | 1.0037 | 1.0029 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7490.088 | 0.9331 | 0.9462 | 2.5415 | |
| MCF12A | NM | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7490.088 | 0.6077 | 0.6441 | 2.5415 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7493.088 | 1.0162 | 1.0307 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7493.088 | 1.0434 | 1.0825 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7493.088 | 0.9874 | 0.9760 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7493.088 | 1.0353 | 1.0672 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7493.088 | 1.0227 | 1.0432 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7493.088 | 1.0287 | 1.0545 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7493.088 | 1.0287 | 1.0545 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7493.088 | 1.0845 | 1.1604 | 1.0513 | |
| MCF7 | HR+ | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7493.088 | 1.1339 | 1.2540 | 1.0513 |