Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7517.088 | 0.9456 | 0.9252 | 1.4687 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7517.088 | 0.7774 | 0.6849 | 1.4687 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7527.088 | 0.9462 | 0.9466 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7527.088 | 0.9551 | 0.9555 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7527.088 | 0.9535 | 0.9539 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7527.088 | 0.9982 | 0.9982 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7527.088 | 0.9842 | 0.9845 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7527.088 | 0.9328 | 0.9330 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7527.088 | 0.9588 | 0.9593 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7527.088 | 0.8935 | 0.8928 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7527.088 | 0.6578 | 0.6293 | 2.0430 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7530.088 | 1.0377 | 1.0350 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7530.088 | 0.9897 | 0.9903 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7530.088 | 1.0119 | 1.0111 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7530.088 | 1.0499 | 1.0462 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7530.088 | 1.0295 | 1.0275 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7530.088 | 0.9671 | 0.9689 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7530.088 | 1.0594 | 1.0549 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7530.088 | 1.1825 | 1.1636 | 2.1310 | |
| SUM149PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7530.088 | 1.0496 | 1.0459 | 2.1310 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7531.088 | 1.0784 | 1.0460 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7531.088 | 1.0064 | 1.0038 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7531.088 | 0.9471 | 0.9675 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7531.088 | 1.0456 | 1.0270 | 3.3184 | |
| SUM159PT | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7531.088 | 0.9121 | 0.9453 | 3.3184 |