Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 1.33 | uM | 7451.088 | 1.0034 | 1.0032 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 6.67 | uM | 7451.088 | 0.9985 | 0.9985 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 33.3 | uM | 7451.088 | 0.8849 | 0.8865 | 2.0920 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7453.088 | 1.0604 | 1.0764 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7453.088 | 1.0029 | 1.0037 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7453.088 | 1.0046 | 1.0059 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7453.088 | 1.0475 | 1.0602 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7453.088 | 1.0110 | 1.0140 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.267 | uM | 7453.088 | 1.0455 | 1.0578 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 1.33 | uM | 7453.088 | 1.0323 | 1.0411 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 6.67 | uM | 7453.088 | 1.1098 | 1.1378 | 1.5634 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 33.3 | uM | 7453.088 | 0.9999 | 0.9998 | 1.5634 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7462.088 | 1.0047 | 1.0252 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7462.088 | 0.9737 | 0.8629 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7462.088 | 0.9293 | 0.6448 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7462.088 | 0.9818 | 0.9047 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7462.088 | 1.0131 | 1.0703 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7462.088 | 0.9517 | 0.7527 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7462.088 | 1.0287 | 1.1566 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7462.088 | 0.9069 | 0.5415 | 0.3753 | |
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7462.088 | 0.8285 | 0.2115 | 0.3753 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7466.088 | 1.0265 | 1.0579 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7466.088 | 0.9582 | 0.9091 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7466.088 | 0.9202 | 0.8268 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7466.088 | 0.9735 | 0.9424 | 0.9180 |