Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9844.001 | 0.0255 | -0.5777 | 2.3587 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10146.001 | 0.9989 | 0.9969 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10146.001 | 1.0557 | 1.1529 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10146.001 | 1.0982 | 1.2716 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10146.001 | 0.9803 | 0.9467 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10146.001 | 0.9022 | 0.7390 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10146.001 | 0.8988 | 0.7300 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10146.001 | 0.8123 | 0.5076 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10146.001 | 0.7723 | 0.4075 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10146.001 | 0.1262 | -0.8800 | 0.7356 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9860.001 | 0.9762 | 0.9704 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9860.001 | 1.0001 | 1.0001 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9860.001 | 1.0373 | 1.0460 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9860.001 | 0.9609 | 0.9512 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9860.001 | 0.4992 | 0.2998 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9860.001 | 0.3676 | 0.0750 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9860.001 | 0.3490 | 0.0409 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9860.001 | 0.3717 | 0.0823 | 1.6119 | |
| SUM229PE | TNBC | - | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9860.001 | 0.0564 | -0.6640 | 1.6119 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9878.001 | 0.9939 | 0.9909 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9878.001 | 1.0121 | 1.0181 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9878.001 | 0.9670 | 0.9505 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9878.001 | 0.9659 | 0.9489 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9878.001 | 0.2947 | -0.1971 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9878.001 | 0.2559 | -0.2775 | 1.3386 |