Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 33.3 | uM | 7430.088 | 0.8895 | 0.8769 | 1.8441 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7436.088 | 0.9897 | 0.9822 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7436.088 | 0.9666 | 0.9424 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7436.088 | 1.0017 | 1.0029 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7436.088 | 0.9540 | 0.9206 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7436.088 | 0.9781 | 0.9622 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 0.267 | uM | 7436.088 | 0.9504 | 0.9143 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 1.33 | uM | 7436.088 | 1.0181 | 1.0311 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 6.67 | uM | 7436.088 | 0.9629 | 0.9359 | 1.1615 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 33.3 | uM | 7436.088 | 0.8711 | 0.7759 | 1.1615 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7437.088 | 0.9951 | 0.9797 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7437.088 | 1.0183 | 1.0769 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7437.088 | 1.0081 | 1.0337 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7437.088 | 1.0184 | 1.0773 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7437.088 | 1.0075 | 1.0314 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.267 | uM | 7437.088 | 0.9756 | 0.8999 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 1.33 | uM | 7437.088 | 0.9651 | 0.8577 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 6.67 | uM | 7437.088 | 1.0009 | 1.0039 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 33.3 | uM | 7437.088 | 0.9032 | 0.6185 | 0.4809 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7451.088 | 0.9793 | 0.9801 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.000427 | uM | 7451.088 | 0.9580 | 0.9594 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.00213 | uM | 7451.088 | 0.9626 | 0.9639 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0107 | uM | 7451.088 | 0.9673 | 0.9684 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.0533 | uM | 7451.088 | 1.0209 | 1.0199 | 2.0920 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 0.267 | uM | 7451.088 | 0.9966 | 0.9968 | 2.0920 |