Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.107 | uM | 5904.092 | 1.0650 | 1.1461 | 0.8933 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.533 | uM | 5904.092 | 0.8071 | 0.5733 | 0.8933 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 2.67 | uM | 5904.092 | 0.9000 | 0.7775 | 0.8933 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 13.3 | uM | 5904.092 | 0.2232 | -0.6269 | 0.8933 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 66.7 | uM | 5904.092 | 0.3298 | -0.4222 | 0.8933 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 5904.098 | 1.0235 | 1.0354 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 5904.098 | 0.9909 | 0.9863 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 5904.098 | 1.0492 | 1.0738 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 5904.098 | 0.9777 | 0.9663 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.107 | uM | 5904.098 | 0.9567 | 0.9343 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.533 | uM | 5904.098 | 0.9097 | 0.8623 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 2.67 | uM | 5904.098 | 0.9634 | 0.9445 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 13.3 | uM | 5904.098 | 0.7353 | 0.5862 | 1.3264 | |
| BT-20 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 66.7 | uM | 5904.098 | 0.5802 | 0.3268 | 1.3264 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 5905.091 | 1.0600 | 1.1330 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 5905.091 | 1.0312 | 1.0692 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 5905.091 | 0.9901 | 0.9782 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 5905.091 | 1.0473 | 1.1049 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 5905.091 | 1.0238 | 1.0528 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 5905.091 | 0.9730 | 0.9403 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 5905.091 | 0.9035 | 0.7878 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 5905.091 | 0.0137 | -0.9826 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 5905.091 | 0.0094 | -0.9886 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 5906.071 | 1.0086 | 1.0250 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00154 | uM | 5906.071 | 1.0237 | 1.0690 | 0.6917 |