Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00768 | uM | 5906.071 | 0.9964 | 0.9896 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0384 | uM | 5906.071 | 1.0279 | 1.0811 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.192 | uM | 5906.071 | 0.9966 | 0.9903 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.96 | uM | 5906.071 | 1.0198 | 1.0576 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 4.8 | uM | 5906.071 | 0.9526 | 0.8645 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 24 | uM | 5906.071 | 0.0195 | -0.9933 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 120 | uM | 5906.071 | 0.0175 | -0.9942 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 5906.091 | 1.0116 | 1.0365 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 5906.091 | 1.1648 | 1.5396 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 5906.091 | 1.0602 | 1.1919 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 5906.091 | 1.1236 | 1.4006 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 5906.091 | 0.9851 | 0.9534 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 5906.091 | 0.9982 | 0.9944 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 5906.091 | 1.0198 | 1.0623 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 5906.091 | 1.1301 | 1.4222 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 5906.091 | 0.0294 | -0.9920 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 5906.098 | 1.0148 | 1.0369 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 5906.098 | 1.0560 | 1.1401 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 5906.098 | 1.0374 | 1.0933 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 5906.098 | 0.9946 | 0.9867 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 5906.098 | 0.9699 | 0.9256 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 5906.098 | 1.0231 | 1.0577 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 5906.098 | 0.9911 | 0.9780 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 5906.098 | 0.9721 | 0.9309 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 5906.098 | 0.8814 | 0.7098 | 0.8050 |