Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7844.001 | 0.5111 | -0.7770 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9402.001 | 0.8071 | 0.4431 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9402.001 | 0.7138 | 0.1969 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9402.001 | 0.7535 | 0.2997 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9402.001 | 0.7883 | 0.3923 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9402.001 | 0.7778 | 0.3640 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9402.001 | 0.7839 | 0.3803 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9402.001 | 0.7654 | 0.3311 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9402.001 | 0.6035 | -0.0732 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9402.001 | 0.4630 | -0.3808 | 0.6567 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7848.001 | 0.9036 | 0.6005 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7848.001 | 0.9908 | 0.9597 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7848.001 | 1.0490 | 1.2220 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7848.001 | 0.9503 | 0.7879 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7848.001 | 0.8936 | 0.5618 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7848.001 | 0.8903 | 0.5492 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7848.001 | 0.7956 | 0.2097 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7848.001 | 0.6579 | -0.2034 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7848.001 | 0.3957 | -0.7395 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7849.001 | 1.0579 | 1.2238 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7849.001 | 0.9884 | 0.9566 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7849.001 | 1.0060 | 1.0225 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7849.001 | 0.9300 | 0.7443 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7849.001 | 0.9181 | 0.7028 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7849.001 | 0.8856 | 0.5908 | 0.5308 |