Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9860.011 | 0.4468 | 0.1525 | 1.4618 | |
| SUM229PE | TNBC | - | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9860.011 | 0.4371 | 0.1354 | 1.4618 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9878.011 | 1.0859 | 1.1315 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9878.011 | 0.9137 | 0.8652 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9878.011 | 0.6252 | 0.3912 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9878.011 | 0.3964 | -0.0218 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9878.011 | 0.3812 | -0.0510 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9878.011 | 0.4085 | 0.0011 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9878.011 | 0.3767 | -0.0596 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9878.011 | 0.2182 | -0.3834 | 1.2938 | |
| SUM52PE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9878.011 | 0.2042 | -0.4142 | 1.2938 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9033.075 | 0.9893 | 0.9777 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00924 | uM | 9033.075 | 0.8906 | 0.7718 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9033.075 | 0.8204 | 0.6259 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9033.075 | 0.7630 | 0.5071 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9033.075 | 0.7576 | 0.4960 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9033.075 | 0.7061 | 0.3898 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9033.075 | 0.6051 | 0.1826 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9033.075 | 0.5937 | 0.1594 | 0.9560 | |
| T47D | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 722 | uM | 9033.075 | 0.4756 | -0.0808 | 0.9560 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 10267.011 | 1.1666 | 2.0716 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 10267.011 | 0.9941 | 0.9675 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 10267.011 | 1.0968 | 1.5864 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 10267.011 | 0.8942 | 0.4652 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 10267.011 | 0.3786 | -0.8661 | 0.3592 |