Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 9664.12 | 0.5777 | -0.2803 | 0.5368 | |
| MDA-MB-415 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 65.6 | uM | 9664.12 | 0.5928 | -0.2449 | 0.5368 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7898.011 | 1.0466 | 1.0897 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7898.011 | 0.8799 | 0.7679 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7898.011 | 1.0033 | 1.0063 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7898.011 | 0.5790 | 0.1810 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7898.011 | 0.4794 | -0.0154 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7898.011 | 0.4334 | -0.1067 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7898.011 | 0.4214 | -0.1307 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7898.011 | 0.4262 | -0.1210 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7898.011 | 0.3636 | -0.2459 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7900.011 | 1.4248 | 2.6161 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7900.011 | 0.8102 | 0.4065 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7900.011 | 1.0545 | 1.1856 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7900.011 | 0.8933 | 0.6560 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7900.011 | 0.6749 | 0.0360 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7900.011 | 0.6701 | 0.0237 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7900.011 | 0.5566 | -0.2496 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7900.011 | 0.6494 | -0.0287 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7900.011 | 0.6181 | -0.1058 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7902.075 | 1.2105 | 1.2049 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00924 | uM | 7902.075 | 0.8331 | 0.8220 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7902.075 | 0.6310 | 0.5810 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7902.075 | 0.3300 | 0.1355 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7902.075 | 0.3864 | 0.2308 | 1.9585 |