Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7870.011 | 0.1449 | -0.1936 | 2.1270 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9551.011 | 1.0313 | 1.0223 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9551.011 | 0.9357 | 0.9527 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9551.011 | 0.7596 | 0.8113 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9551.011 | 0.3542 | 0.3758 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9551.011 | 0.3701 | 0.3978 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9551.011 | 0.2741 | 0.2544 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9551.011 | 0.1690 | 0.0537 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9551.011 | 0.1642 | 0.0427 | 2.7742 | |
| MCF 10A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9551.011 | 0.1677 | 0.0507 | 2.7742 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9566.011 | 0.9399 | 0.9477 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9566.011 | 0.9076 | 0.9186 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9566.011 | 0.7736 | 0.7918 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9566.011 | 0.5680 | 0.5699 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9566.011 | 0.5387 | 0.5347 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9566.011 | 0.3622 | 0.2948 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9566.011 | 0.2439 | 0.0932 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9566.011 | 0.2067 | 0.0183 | 2.3358 | |
| MCF 10F | NM | - | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9566.011 | 0.1887 | -0.0206 | 2.3358 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7873.011 | 1.0020 | 1.0019 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7873.011 | 1.0208 | 1.0199 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7873.011 | 0.8656 | 0.8660 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7873.011 | 0.4002 | 0.2880 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7873.011 | 0.2592 | 0.0454 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7873.011 | 0.2279 | -0.0173 | 2.0810 |