Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7873.011 | 0.1305 | -0.2483 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7873.011 | 0.0895 | -0.3727 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7873.011 | 0.1005 | -0.3371 | 2.0810 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.000168 | uM | 10061.12 | 1.0133 | 1.0128 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00084 | uM | 10061.12 | 1.0170 | 1.0164 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0042 | uM | 10061.12 | 0.9471 | 0.9481 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.021 | uM | 10061.12 | 0.8728 | 0.8726 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.105 | uM | 10061.12 | 0.5413 | 0.4861 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 0.525 | uM | 10061.12 | 0.5593 | 0.5099 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 2.62 | uM | 10061.12 | 0.3781 | 0.2493 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 13.1 | uM | 10061.12 | 0.2943 | 0.1068 | 2.0669 | |
| MCF12A | NM | Basal B | Gemcitabine | DNA replication | DNA replication | 65.6 | uM | 10061.12 | 0.2730 | 0.0671 | 2.0669 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7875.011 | 0.9371 | 0.9249 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7875.011 | 0.8833 | 0.8589 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7875.011 | 0.7218 | 0.6503 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7875.011 | 0.7470 | 0.6839 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7875.011 | 0.6879 | 0.6040 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7875.011 | 0.6992 | 0.6196 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7875.011 | 0.6147 | 0.5011 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7875.011 | 0.6228 | 0.5127 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7875.011 | 0.6701 | 0.5795 | 1.6960 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9583.011 | 1.1137 | 1.2178 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9583.011 | 1.0343 | 1.0657 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9583.011 | 1.0019 | 1.0036 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9583.011 | 0.8266 | 0.6660 | 1.0421 |