Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9583.011 | 0.8098 | 0.6334 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9583.011 | 0.8210 | 0.6552 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9583.011 | 0.8106 | 0.6351 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9583.011 | 0.8130 | 0.6396 | 1.0421 | |
| MCF7 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9583.011 | 0.8083 | 0.6306 | 1.0421 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0185 | uM | 10077.119 | 1.0133 | 1.0496 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 10077.119 | 0.9549 | 0.8352 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 10077.119 | 1.0911 | 1.3525 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 10077.119 | 1.0025 | 1.0094 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 11.5 | uM | 10077.119 | 1.0582 | 1.2222 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 57.7 | uM | 10077.119 | 1.0344 | 1.1300 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 289 | uM | 10077.119 | 1.0829 | 1.3196 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 10077.119 | 0.8278 | 0.4069 | 0.5371 | |
| MDA-MB-134-VI | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 10077.119 | 0.0164 | -0.9991 | 0.5371 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7885.011 | 0.9504 | 0.8101 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7885.011 | 1.0182 | 1.0718 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7885.011 | 0.7854 | 0.2457 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7885.011 | 0.6903 | -0.0329 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7885.011 | 0.6959 | -0.0172 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7885.011 | 0.7717 | 0.2034 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7885.011 | 0.7288 | 0.0758 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7885.011 | 0.7050 | 0.0079 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7885.011 | 0.7613 | 0.1717 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7886.011 | 0.9581 | 0.8803 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7886.011 | 0.9487 | 0.8538 | 0.6942 |