Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7886.011 | 0.7602 | 0.3473 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7886.011 | 0.6063 | -0.0273 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7886.011 | 0.6736 | 0.1319 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7886.011 | 0.6447 | 0.0626 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7886.011 | 0.6929 | 0.1791 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7886.011 | 0.6640 | 0.1089 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7886.011 | 0.6082 | -0.0228 | 0.6942 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7892.011 | 0.9760 | 0.9815 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7892.011 | 0.9442 | 0.9566 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7892.011 | 0.6963 | 0.7417 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7892.011 | 0.5786 | 0.6229 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7892.011 | 0.5423 | 0.5832 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7892.011 | 0.5677 | 0.6111 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7892.011 | 0.4120 | 0.4254 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7892.011 | 0.3780 | 0.3793 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7892.011 | 0.3700 | 0.3681 | 2.6182 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7896.011 | 0.9938 | 0.9886 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 7896.011 | 0.9750 | 0.9540 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 7896.011 | 0.7152 | 0.4708 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 7896.011 | 0.4946 | 0.0488 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 7896.011 | 0.4884 | 0.0368 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 7896.011 | 0.4510 | -0.0364 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 7896.011 | 0.4394 | -0.0592 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 7896.011 | 0.4398 | -0.0584 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 7896.011 | 0.4366 | -0.0646 | 1.0906 |